Moreover, overexpression of LRP5 restored NUP37 knockdown-induced downregulation of YAP/TEAD signaling target gene CTGF, suggesting that LRP5 acts as a genuine regulator of YAP/TEAD signaling, while also implicating LRP5 as a promising therapeutic target for preventing HCC proliferation. The gene discussed is LRP5; the disease is hepatocellular carcinoma.