Moreover, wild type SOX13 expression also restores the mRNA level of Aurora B and Cyclin B1, in parallel with the upregulated expression of PAX8 to a certain extent (Fig. 3g), suggesting the notion that SOX13-regulated PAX8 expression affects the expression pattern of Aurora B and Cyclin B1 in stomach cancer. The gene discussed is CCNB1; the disease is gastric cancer.