Based on the aforementioned exploration of literature and question to be explored, we subsequently proposed the hypothesis that the let-7 family of miRNAs influences the immune evasion of HNSCC by regulating TCF-4 and PD-L1 via the β-Catenin/STT3 pathway, with the objective of verifying this hypothesis through a series of experiments and ultimately providing enhanced clinical insight for treating HNSCC. Here, CD274 is linked to head and neck squamous cell carcinoma.