The transcription factor 4 (TCF-4) (also ITF2, SEF2 or E2–2) is a commonly widely considered to be a broadly expressed basic helix–loop–helix (bHLH) protein that serves as a homo- or heterodimer [13], with reports highlighting the tumor-suppressive capabilities of TCF-4 in tumors such as the Sonic hedgehog (SHH) medulloblastoma [13, 14]. The gene discussed is TCF4; the disease is medulloblastoma.