The negative association of irisin with HOMA-IR and insulin in patients with nonalcoholic fatty liver disease (NAFLD) was also demonstrated by Shanaki M et al [25] A negative association of HOMA-IR and circulating irisin levels in young girls demonstrated in a recent study indicate that the onset of obesity, insulin resistance and T2DM might be delayed by the irisin secretion at an early age [26]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.