Interestingly, we also analyzed the impact of aberrant AGGF1 mRNA expression on CRC patient survival by using the public dataset from TCGA and discovered that there was no significant association between the expression of AGGF1 and OS (Additional file 4: Fig. S4), which further demonstrates that AGGF1 plays significant roles in tumorigenesis and the progression of CRC at the protein level rather than the mRNA level. Here, AGGF1 is linked to colorectal carcinoma.