While we could replicate some of the previously reported fractional anisotropy reductions in asymptomatic APOE4 carriers, we found no evidence of divergence between MAPT/GRN carrier-control differences and APOE4 carrier-control differences, even when restricting our DTI analysis to regions which are known to differ between FTD and AD patients. The gene discussed is APOE; the disease is frontotemporal dementia.