CSF3 and Decreased total neutrophil count: However, considering the common occurrence of grade ≥ 3 neutropenia, the higher proportion of cycle initiation delay in the trifluridine/tipiracil plus bevacizumab group, and the patient population in salvage setting, appropriate supportive intervention with G-CSF or temporary dose interruptions were still important for safety management with trifluridine/tipiracil plus bevacizumab.