The peripheral inflammatory response (plasma levels of IL-6 and IL-1β) induced by MCAO was not seriously increased compared with that induced by LPS only, but it was responded much more profoundly in the brain homogenate (Fig. 4d–f), suggesting the inflammatory response induced by MCAO was concentrated in the cerebral ischemia parts at the acute stage. This evidence concerns the gene IL1B and Cerebral ischemia.