MKI67 and neoplasm: To estimate the ki67-index for a specific tumor region, T, when all the nuclei (positive for ki67 and negative for ki67) are found in all the sub-images belonging to T, the segmentation results are recomposed to compute the final ki67-index estimate for T as the percentage of all the ki67 positive nuclei detected in T (i.e. the sum of the positive nuclei in all sub-images extracted from T), with respect to all the nuclei detected in T.