Promoter methylation analysis of the region 2000bp upstream of the TSS of FGFR2 and ESRP1 revealed that most tumor samples from cohort #1 (datasets #3 and #4), cohorts #2, #3 and #4 were hypo/demethylated for both gene promoters (Figure 1f,h,i). This evidence concerns the gene FGFR2 and neoplasm.