Previously, we showed the tumor promoting effect of mesenchymal stem cell (cancer associated fibroblast)-derived galectin-1 in the 4T1 model [9], and later on we screened an anti-cancer compound library of imidazo[1-2-b]pyrazole-7-carboxamides in both two- and three-dimensional cell cultures of 4T1 cells [10,11]. Here, LGALS1 is linked to cancer.