In these GO categories genes such as alpha-2-HS-glycoprotein (AHSG), histidine-rich glycoprotein (HRG), FN1, ORM1, ORM2, TMPRSS13, ACTG1, haptoglobin-related protein (HPR), alpha-1-microglobulin/bikunin precursor (AMBP), APOA2, group-specific component (GC), ITIH1, ITIH2, acrosin binding protein (ACRBP) and PEBP1 were predicted as novel prognostic or diagnostic biomarkers and new therapeutic target in CAD. The gene discussed is ITIH2; the disease is coronary artery disorder.