In this network genes such as HEPACAM2, calcyclin binding protein (CACYBP) and N-ethylmaleimide-sensitive factor attachment protein, gamma (NAPG) along TFs such as FOXC1, FOXL1, YY1 and USF2 were predicted as novel prognostic or diagnostic biomarkers and new therapeutic target in CAD. The gene discussed is YY1; the disease is coronary artery disorder.