In these pathways genes such as HSD17B11, ABCB4, ABCC2, ABCA6, FANCD2, UBE2D3, NPM1, PSMA3, methionyl-tRNA synthetase (MARS), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), v-myc myelocytomatosis viral oncogene homolog (avian) (MYC) and TERF1 were predicted as novel prognostic or diagnostic biomarkers and new therapeutic target in CAD. The gene discussed is TERF1; the disease is coronary artery disorder.