In this network down regulated genes such as KH-type splicing regulatory protein (FUSE binding protein 2) (KHSRP), MLLT1 and DDIT4 along with miRNA such as hsa-mir-548ac, hsa-mir-6890-3p, hsa-mir-5681a, hsa-mir-3135b and hsa-mir-3607-3p were predicted as novel prognostic or diagnostic biomarkers and new therapeutic target in CAD. This evidence concerns the gene DDIT4 and coronary artery disorder.