Polymorphism in genes such as MT1A [85], MT2A [86], CYP2C9 [87], CYP3A4 [88], fibrinogen beta chain (FGB) [89], ADH1C [90], lipoprotein, Lp(a) (LPA) [91] and APOC3 [92] were liable for advancement of CAD. The gene discussed is MT2A; the disease is coronary artery disorder.