The analysis from The Human Protein Atlas indicated that the expression of hub genes (up regulated) such as NPM1, ATM, TRIP6, HSP90B1 and HIST1H1C are enhanced in CAD smooth muscle tissue (Figure 16), whereas, the expression of hub genes (down regulated) such as UBC, FN1, RPL14, UBB and EEF1A1 are reduced in CAD smooth muscle tissue (Figure 17). The gene discussed is ATM; the disease is coronary artery disorder.