Down regulated genes such as ACAT1, ADH1A, ADH1C, ADH4, ACAA2, ALDH1A1, ALDH2, CYP2C9, CYP2E1, CYP3A4 were involved in centralized pathway of fatty acid metabolism was associated with pathogenesis of CAD [94]. This evidence concerns the gene ADH1A and coronary artery disorder.