IDH1 and hepatocellular carcinoma: Moreover, NF-κB regulates the transcription of aconitase 2, isocitrate dehydrogenase 3A (IDH3A), and succinyl-CoA ligase (SUCLA2) genes encoding three TCA cycle enzymes and IDH1 gene encoding a TCA-related protein in HCC cells (Figure 1) [53].