INS and Insulin resistance: In another randomized, double-blinded and placebo-controlled clinical study by Chuengsamarn et al. [80], supplementation of curcumin (750 mg/twice per day; 1500 mg/day) to T2DM individuals resulted in significantly reduced serum triglyceride, leptin and insulin levels and HOMA-IR, while adiponectin levels were increased, suggesting reduced insulin resistance and inflammation [80].