The increase in complement factors and RELB together could also point to the inflammatory component of the disease as they have been reported as histopathological signs of myositis.56 Tissue damage, complement deposition, and increased calcium levels represent calcification triggers, which seem to be counteracted by expression of matrix Gla protein (MGP), which we found to be increasing with age in DMD patients. This evidence concerns the gene MGP and myositis disease.