After determining the role of LINC00673 in prostate cancer cell proliferation and cell cycle, the focus of the experiment turned to elucidating the effects of LINC00673 on drug resistance in prostate cancer cells by regulating methylation of the KLF4 gene promoter with DU145 cells receiving treatment of pcDNA‐KLF4, pcDNA‐LINC00673 or both. This evidence concerns the gene KLF4 and prostate carcinoma.