Pathway analysis of host genes enriched with H3K27me3 in non-tumorigenic K-Pα(+)S MSC showed that the most repressed genes were all related to KS and KSHV oncogenic signaling, further indicating that distinct environments where KSHV infection occurs can lead to different host epigenetic landscape, thus prompting oncogenesis. This evidence concerns the gene LRP1 and Kaposi's sarcoma.