Our data suggest that PDGFRA-positive KSHV MSCs growing in a pro-angiogenic KS-like environment (K-Pα(+)S KS) display a unique KSHV transcriptional profile that encompasses enhanced expression of oncogenic KSHV genes, without KSHV completing its full viral lytic cycle (abortive lytic state), which likely leads to KSHV-induced tumorigenicity. Here, PDGFRA is linked to Kaposi's sarcoma.