Moreover, we found that activation of PDGFRA signaling in induced K-Pα(+)S KS cells correlated with upregulation of its ligands PDGFA and PDGFB (Fig 6C), further confirming the fact that KSHV lytic expression induces ligand-mediated activation of this oncogenic driver [14]. This evidence concerns the gene LRP1 and Kaposi's sarcoma.