Tumors that arise from K-Pα(+)S KS cells have an increased expression of KSHV oncogenes (KSHV in vivo lytic switch), paralleling our previous findings in the mouse KS-like mECK36 model [26], and also displayed PDGFRA signaling activation that co-distributed with KSHV LANA, thus supporting the described link between KSHV and PDGFRA activation in the tumors [14]. This evidence concerns the gene LRP1 and Kaposi's sarcoma.