In K-Pα(+)S MSC cells the most repressed genes involved NOTCH1 regulation, signaling by NOTCH1 in Cancer, VEGFA-VEGFR2 pathway, TGFBR1/2 KD mutants in cancer, VEGFR2-mediated cell proliferation, signaling by VEGF and p53 signaling pathways (Fig 4G). Here, TP53 is linked to cancer.