Moreover, and as we showed for KSHV gene expression (Fig 3), H3K27me3 and H3K4me3 ChIP-seq revealed slightly more H3K4me3 enrichment (Fig 4C) and fewer H3K27me3 (Fig 4D) at the promoters of these upregulated genes in tumorigenic K-Pα(+)S KS cells, further confirming epigenetic regulation of transcription at these loci. Here, LRP1 is linked to Kaposi's sarcoma.