These findings correspond well to the results of previous studies, which also observed lower bone mineral density [67], higher serum PTH [38, 46, 67–70], higher serum OPG [61, 62, 67, 68, 71, 72], and lower sRANKL [61, 62] in patients with renal insufficiency. This evidence concerns the gene TNFRSF11B and Renal insufficiency.