Here, OPG was significantly higher in patients with stage 3 renal insufficiency (mean, 6.81 ± 0.63 pmol/L) compared to those with stage 1 disease (4.75 ± 0.28 pmol/L) or stage 2 disease (4.78 ± 0.28 pmol/L; Mann-Whitney, p = 0.003 and 0.005, respectively). Here, TNFRSF11B is linked to Renal insufficiency.