The validation of some of these molecular biomarkers for diagnosis and prognosis has prompted WHO to include molecular subclasses into their latest classification schema for CNS tumors, including addition of MGMT methylation and IDH-mutant/IDH-wildtype classifications for glioblastoma, as well as IDH-mutant and 1p/19q-codeleted classifications for oligodendrogliomas and anaplastic oligodendrogliomas [13]. Here, IDH1 is linked to central nervous system neoplasm.