The genomic profiling depicted what is already known about glial tumors, (the mutual exclusivity of IDH1 mutations with EGFR and PTEN mutations, the co-existence of ATRX mutations only within a subset of IDH1 low grade tumors, etc), but also revealed the heretofore unknown frequent, diminished molecular heterogeneity of IDH1mt low grade tumors. Here, ATRX is linked to glioma.