NES and central nervous system cancer: Univariate and multivariate analysis of biomarker expression in the treatment-naïve glioma cohort showed significantly lower values for vimentin (p = 0.0002), VEGFR2 (p = 0.0002), nestin (p = 0.003), Ki67 (p = 0.006) and HLA1 (p = 0.008) proteins in IDHmt vs wt tumors (S6A Fig).