Analysis of chromatin modification [32] and MITF-SOX10 [29] binding profiles showed that the DIRC3 locus contains three sites of MITF-SOX10 co-occupancy in melanoma: one upstream of the DIRC3 TSS (BS1) and two within the DIRC3 gene body (BS3-BS4, Fig 2A). This evidence concerns the gene DIRC3 and melanoma.