Using chromatin state maps from tumorigenic melanocytes [32], we determined that compared to all other melanocyte and melanoma expressed lncRNAs, MITF-SOX10 bound lncRNA loci displayed increased levels of H3K27ac and H3K4me1 modified chromatin, as well as a corresponding higher ratio of the H3K4me1:me3 enhancer-associated chromatin signature, (p<0.05, two-tailed Mann Whitney U test, Fig 1B and S1 Fig). Here, ME3 is linked to melanoma.