In order to evaluate the potential effects of disruption of circadian clock in thoracic cancer patients, we attempted to compute the activities of hallmark pathways including TSC/mTOR, RTK, RAS/MAPK, PI3K/AKT, Hormone ER, Hormone AR, EMT, DNA Damage Response, Cell Cycle, and Apoptosis pathways. Here, CLOCK is linked to thoracic cancer.