Our study found that macrophages obtained from the amniotic membrane of GDM mothers presented a higher expression of MCP‐1 (and a notably trend in other pro‐inflammatory genes) than those obtained from controls, suggesting they have a more pro‐inflammatory profile predisposition, even in GDM women with a good metabolic control according to their third trimester HbA1c concentrations. This evidence concerns the gene CCL2 and gestational diabetes.