As concerned to why Prrx2 gene expression is elevated in cardiac fibroblasts after MI, an underlying mechanism is through the production of TGF‐β, which is a key factor contributing to cardiac fibrosis in heart diseases35 and TGF‐β is able to induce both Prrx2 in cancer cells.16 Here, TGFB1 is linked to myocardial infarction.