As reported, both Prrx2 and Wnt5a were able to be up‐regulated by TGF‐β in myofibroblast and cancer cell.16, 17 Therefore, we have been suggested that Wnt5a gene expression is directly up‐regulated by Prrx2, which mediates cardiac fibrosis and delays the recovery of cardiac functions after MI. Here, PRRX2 is linked to fibrosis.