As reported, both Prrx2 and Wnt5a were able to be up‐regulated by TGF‐β in myofibroblast and cancer cell.16, 17 Therefore, we have been suggested that Wnt5a gene expression is directly up‐regulated by Prrx2, which mediates cardiac fibrosis and delays the recovery of cardiac functions after MI. This evidence concerns the gene PRRX2 and cancer.