Wnt signal is relatively silent in adult heart tissue,7 but re‐activated after a variety of cardiac injuries ranging from acute ischaemic insult to chronic pressure overloading.8 Abnormal Wnt pathway activation contributes to transforming growth factor‐beta (TGF‐β)‐induced fibrotic remodelling in numerous adult fibrotic diseases including cardiac fibrosis after MI.9 Wnt pathway has revealed new points of intervention that may lead to novel drug targets for small molecular weight compounds.10, 11 However, how Wnt signalling is dysregulated in post‐ischaemic heart needs further investigations. Here, TGFB1 is linked to myocardial infarction.