TFAP2C is a transcription factor involved in craniofacial and skeletal development and in the maintenance of pluripotency; high levels of expression have been reported in mammary and germ cell tumors.25,26BMP7 encodes a secreted ligand in the transforming growth factor–β family and plays an important role in brown adipose tissue, bone, and kidney development; it may also influence appetite regulation.27,28. Here, TFAP2C is linked to testicular germ cell tumor.