Belonging to zinc fingers and homeoboxes gene family that were nuclear homodimeric transcriptional repressors,28ZHX2 was implicated in various human diseases, such as podocyte disease,29 multiple myeloma30 and hepatocellular carcinoma (HCC).31, 32, 33 In particular, ZHX2 was found to inhibit HCC proliferation in vitro and in vivo by reducing the expression of Cyclins A and E, with a lower nuclear level in HCC samples.34 It highly suggested the tumour‐suppressing role that ZHX2 played in carcinogenesis. This evidence concerns the gene CCNA2 and neoplasm.