All the above‐mentioned results demonstrated that lncRNA F11‐AS1–impaired miR‐211‐5p–targeted inhibition of NR1I3 could impede the proliferation, apoptosis, migration and invasion of HepG2.2.15 cells, ultimately preventing development and progression of HBV‐related HCC. Here, NR1I3 is linked to hepatocellular carcinoma.