The functionality of NR1I3, an important regulator of drug metabolism and cancer development, is mediated via modulation of transcription of target genes.13 Therefore, we proposed a hypothesis that the interactions among lncRNA F11‐AS1/miR‐211‐5p/NR1I3 axis might be involved in tumorigenesis of HBV‐related HCC, and the subsequent experiments in the current study were performed to study the effects of this axis on the physiological functions of stably HBV‐expressing HepG2.2.15 cells. The gene discussed is NR1I3; the disease is cancer.