In addition, NR1I3 has also been documented to exert its regulatory role in breast cancer and colorectal cancer, especially in hepatocarcinogens.25, 26, 27 Then, NR1I3 expression in HBV+/HBV− HCC tissues and corresponding adjacent tissues was examined by RT‐qPCR and Western blot analysis. The gene discussed is NR1I3; the disease is hepatocellular carcinoma.