Similarly, down‐regulation of lncRNA F11‐AS1 has also been reported in PDAC, and modulation in its expression has been suggested as a new possible biomarker for the diagnosis and treatment of patients with PDAC.6 Subsequently, we investigated the cause for triggering lncRNA F11‐AS1 down‐regulation in HCC and discovered that the HBx protein was the primary inhibitor of lncRNA F11‐AS1. This evidence concerns the gene F11 and hepatocellular carcinoma.