EZH2 and neoplasm: In addition, Huang et al discovered that lncRNA Dreh was negatively regulated by the HBx protein via microarray analyses.18 Moreover, Hu et al revealed that lncRNA UCA1, which was up‐regulated by the HBx protein, promoted cell growth and tumour formation via recruitment of EZH2 and inhibition of p27Kip1/CDK2 signalling.19 Although the HBx protein was found to down‐regulate the expression of lncRNA F11‐AS1 in the current study, the underlying mechanism behind HBx protein resulting in this alteration still warrants further investigation.