PFKFB3 is a key regulator in glycolytic metabolism, and its role in cancer cells has been well‐established.29 In recent studies, blockage of PFKFB3 suppressed the growth of various cancer cells, such as head and neck squamous cell carcinoma cells 17 and breast cancer cells.30 However, studies investigating the function of PFKFB3 in macrophage cells mostly focused on the relationship between glycolytic metabolism and immune defence,31, 32 and the role of PFKFB3 during osteoclast differentiation remains unclear. Here, PFKFB3 is linked to breast cancer.