In addition, PFKFB3 has been reported as a mediator of circadian control of cancer growth.18 Moreover, based on the results of a recent study, PFKFB3 radiosensitized cancer cells and suppressed homologous recombination.19 However, the function of PFKFB3 during osteoclastogenesis remains obscure. This evidence concerns the gene PFKFB3 and cancer.