Strikingly, Tregs are effective to maintain Th1/Th2 balance and dampen excessive pro‐inflammatory response and immunopathology during early‐phase of sepsis.1, 3 In the current study, we evaluated Treg‐mediated Th1/Th2 balance and associated cytokines including IL‐2, IL‐4 and IFN‐γ. The gene discussed is IL4; the disease is Sepsis.