Of note, three studies that inhibit inflammatory nuclear factor kappa b (NF‐κB) signaling in all GFAP‐expressing astrocytes (including work from our group) report feeding phenotypes, namely, increased initial intake of a high‐fat diet following initial exposure, resistance to the obesity phenotype when already on a high‐fat diet and protection from metabolic dysfunction and weight gain on a high fat diet (Buckman et al., 2015; Douglass, Dorfman, Fasnacht, Shaffer, & Thaler, 2017; Zhang et al., 2017). This evidence concerns the gene NFKB1 and Obesity.