In this study, we have shown that SLAMF9‐deficient mice have impaired clearance of systemic Salmonella infection, and suppression of SLAMF9 expression in human THP‐1 cells dramatically reduces their ability to produce pro‐inflammatory cytokines TNF‐α, IL‐1β and GM‐CSF. The gene discussed is CSF2; the disease is Salmonella Infections.