Previous studies demonstrated that repeated stimulation of the kidneys by sepsis led to the production of a large number of pro-inflammatory cytokines including TNF-α and IL-6 through nuclear factor-kappa B (NF-κB) signaling pathway, which is a key regulator in keeping homeostasis of immune system and a major drug target in a variety of diseases [24,25]. The gene discussed is NFKB1; the disease is Sepsis.