We recently demonstrated that 1,25(OH)2D exerts an anti‐aging role by activation of Nrf2‐antioxidant signaling and inactivation of p16/p53 senescence signaling (Chen et al., 2019); however, it is unclear whether 1,25(OH)2D plays a role in protection against osteoporosis through its anti‐aging mechanisms. The gene discussed is TP53; the disease is osteoporosis.