We further determined the levels of APN isoforms in NAFLD patients on high‐fat diets and the control subjects, and found that serum HMW and MMW APN were significantly lower (P < .01 and P < .001, respectively) in NAFLD patients on a high‐fat diet compared with those in the corresponding control subjects (Figure 1C). Here, ANPEP is linked to metabolic dysfunction-associated steatotic liver disease.