With regard to FZD8, so far, data in the literature are contradictory, with some reports showing the capacity of FZD8 to stimulate malignant transformation of cancer cells,39 and others showing its involvement in reducing tumor initiating capacity.32 In line with our data that showed low expression of FZD8 in CSCs, analysis of the TCGA data sets showed unfavorable prognosis in the cases of pancreatic cancers with low FZD8 expression. Here, FZD8 is linked to cancer.