Eventually, rs4808844 and its proxies may affect the expression of multiple genes in different tissues, including the ceramide synthase 1 (CERS1) in the adrenal gland [50], a gene which has been involved in the regulation of metabolic features such as obesity-induced insulin resistance [55] and fat metabolism [56]. This evidence concerns the gene CERS1 and obesity due to melanocortin 4 receptor deficiency.