PSEN1 and Alzheimer disease: Bin1−/− and APP/PS1 mice showed significant positive correlation (r = 0.1–0.2, p < 0.05) with AMP-AD immune response associated modules in Consensus Cluster B as well as AMP-AD neuronal modules in Consensus Cluster C. The cell cycle and RNA non-mediated decay pathways enriched AMP-AD modules in Consensus Cluster D were significantly negatively correlated (r = − 0.2, p < 0.05) with Apoe−/−, APOEε4, Clu−/−, Cd2ap+/, and APP/PS1 mice, but Bin1+/− mice showed significant positive correlation (r = 0.11, p > 0.05) with AMP-AD cell cycle module in the cerebellum (Fig. 6).