PSEN1 and Alzheimer disease: The APP/PS1-driven orange and darkorange modules overlapped with lipid processing and metabolism associated AMP-AD modules in Consensus Cluster E, the lightgreen module overlapped with immune system modules Consensus Cluster B, and the lightyellow module overlapped with both microglia and organelle biogenesis related AMP-AD modules in Consensus Clusters B and E, respectively (Fig. 4; p < 0.05).