Furthermore, Clu−/−and Cd2ap+/− mice showed significantly positive association (r = 0.1, p < 0.05) with AMP-AD neuronal modules in Consensus Cluster C and negative correlation (r = − 0.15, p < 0.05) with AMP-AD immune related modules in Consensus Cluster B (Fig. 6). This evidence concerns the gene CLU and Alzheimer disease.