Activation of neuroinflammatory microglia by interferon (IFN)-γ or lipopolysaccharide (LPS) induced reactive astrogliosis by secreting cytokines, interleukin 1 (IL-1), tumor necrosis factor (TNF), and complement component 1q [5], which can ultimately lead to neuronal loss during the process of neurodegenerative diseases [6]. Here, TNF is linked to neurodegenerative disease.