TNFSF10 and non-small cell lung carcinoma: Cholesterol depletion significantly reduced the ability of another member of TNFRSF - death receptor 5 (DR5) to initiate apoptosis [37], indicating the role of cholesterol-rich micro-domains in pro-apoptotic signaling initiated by DR5 ligand TRAIL in TRAIL-sensitive non-small-cell lung carcinoma (NSCLC) cells [38].