In the SUPREME-HN study, PD-L1 expression using TCs at cutoff values of 10%, 25%, and 50% was not prognostic for survival in patients with HNSCC treated with standard therapies; however, PD-L1 expression may be positively or negatively prognostic when anatomic subsites within the head and neck are considered. The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.