Both a comprehensive review (4203 patients from 10 studies) and meta-analysis (10,300 patients from 22 studies) investigated the systemic safety profile of IVA and IVR respectively, in DMO, neovascular age-related macular degeneration and retinal vein occlusion, by pooling data from existing randomised controlled trials but found no difference in the incidence of adverse systemic events between either intravitreal anti-VEGF treatment and placebo [30, 31]. Here, VEGFA is linked to wet macular degeneration.