Isoliquirtigenin, a chalcone-type flavonoid derived from licorice root, directly targets GRP78 (HSP70) and suppresses cancer cell colony formation through inhibition of GRP78 (HSP70)-mediated β-catenin/ABCG2 signaling in breast cancer stem cells [187,188] (Table 6). Here, HSPA5 is linked to breast carcinoma.