Since HSP90 serves to promote the transcription and expression of vascular endothelial growth factor receptors (VEGFRs), the major receptors involved in endothelial cell-dependent tumor angiogenesis, HSP90 overexpression leads to the enhanced proliferation, migration, invasion, and tube cell-dependent tumor angiogenesis in vitro and in vivo [75]. This evidence concerns the gene HSP90AA1 and neoplasm.