Investigating the functional mechanism of HSP40 in cancer, Yang et al. demonstrated that Hsp40 DNAJ member A1 (DnaJA1) is transcribed by E2F transcription factor 1 and promotes cell cycle progression by inhibiting ubiquitin degradation of cell division cycle protein 45 (CDC45) in CRC [32]. This evidence concerns the gene DNAJA1 and colorectal carcinoma.