BAG3 and colonic neoplasm: Since HSP70/BAG complexes protect cancer cells from apoptosis through stabilization of anti-apoptotic Bcl-2 family member proteins, the downregulation of HSP70/BAG3 significantly reduces the levels of BCL-2, BCL-XL, and myeloid cell leukemia 1 (MCL-1) proteins in human HCT-116 colon cancer cells [173].