HK2 and renal cell carcinoma: In this way, we identified strong correlations between downregulated miR-374b-5p and its upregulated target genes HIST1H3B, HK2, and SLC7A11, and also between upregulated miR-26b-5p and its downregulated target genes PPARGC1A, ALDH6A1, and MARC2. Among the upregulated target genes, HIST1H3B has not yet been described to play any role in renal cell carcinomas.