HK2 and metabolic disease: Based on the finding that among the deregulated genes in CDCs were genes that regulate (i) the transport of amino acids or electrolytes (SLC7A11, SLC47A1), (ii) mitochondrial pathways (MARC2, PPARGC1A), and (iii) catabolic pathways (HK2, ALDH6A1), we can support the statement that CDC is a metabolic disease [6].