In this way, we identified strong correlations between downregulated miR-374b-5p and its upregulated target genes HIST1H3B, HK2, and SLC7A11, and also between upregulated miR-26b-5p and its downregulated target genes PPARGC1A, ALDH6A1, and MARC2. Among the upregulated target genes, HIST1H3B has not yet been described to play any role in renal cell carcinomas. This evidence concerns the gene MTARC2 and hereditary clear cell renal cell carcinoma.