Based on the finding that among the deregulated genes in CDCs were genes that regulate (i) the transport of amino acids or electrolytes (SLC7A11, SLC47A1), (ii) mitochondrial pathways (MARC2, PPARGC1A), and (iii) catabolic pathways (HK2, ALDH6A1), we can support the statement that CDC is a metabolic disease [6]. Here, PPARGC1A is linked to metabolic disease.