PBMCs from tumor-bearing mice (Figure 5A), which were similar to PBMCs (Supplementary Figure S5A,C) and NK cells (Supplementary Figure S5B,D) from pancreatic cancer patients, had significantly lower NK cell-mediated cytotoxicity and exhibited decreased IFN-γ secretion, when compared to those from healthy mice or humans, respectively. This evidence concerns the gene IFNG and pancreatic neoplasm.