The single injection of super-charged NK cells in tumor-bearing mice resulted in an increased surface receptor expression of PD-L1, CD54, and MHC-class I on tumor cells exhibiting decreased tumor growth and the loss of susceptibility of tumor cells to NK cell-mediated cytotoxicity (Figure 4L–O), potentially paving the road for their increased susceptibility to cytotoxic T lymphocyte (CTL) mediated killing due to increased MHC-class I expression. The gene discussed is ICAM1; the disease is neoplasm.