When PBMCs (Figure 5A–C), splenocytes (Figure 5D,F), enriched-NK cells from splenocytes (Figure 5G,H), huCD3+ T cells from splenocytes (Figure 5I), and BM-derived immune cells (Figure 5J–L) were assessed for NK cytotoxicity and/or secretion of IFN-γ, tumor-bearing mice had much lower cytotoxicity and/or secretion of IFN-γ in cells obtained from all tissue compartments, in comparison to those obtained from control mice without tumor, or tumor-bearing mice injected with NK cells, or those implanted with NK-differentiated tumors (Figure 5). This evidence concerns the gene IFNG and neoplasm.