We were also able to use CpG-ODN injection to suppress tumor growth in our syngeneic model (Figure 3B and Figure S3F), demonstrating that tumor regression correlates with increased CD8+ T cell infiltration of tumors (Figure 3C,D), and successful conversion of a “cold” tumor into a “hot” one by CpG-ODN. The gene discussed is CD8A; the disease is neoplasm.