ATG5 and Iron deficiency anemia: Adult ATG5 knockout mice that express ATG5 in the brain show similar abnormalities as the ATG7 knockout (except the neurodegeneration phenotype), but in addition also display abnormalities related to inflammatory responses, in particular in the kidney, liver, spleen, and lymph nodes, as well as atrophy of sex organs and anaemia, resulting from iron deficiency [34].