PDP1 and colorectal carcinoma: Mock- and GSNOR-silenced CRC HCT116 cells were incubated for 24 h in presence of 10 mM dichloroacetate (DCA) (Figure 5a), an agent that induces loss of pyruvate dehydrogenase (PDH) phosphorylation with parallel enhancement of oxidative metabolism, production of nitric oxide (NO) and consequent protein nitrosylation [18] or under hypoxia (Figure 5b), a condition that results in increased NO production [19].