TRAP1 and cancer: Indeed, TRAP1 is co-upregulated in the majority of human CRCs with its network of client/related proteins and, through them, regulates several key functions of cancer cells and, among others, adaptation to stress and protection against apoptosis and cytotoxic agents (i.e., oxaliplatin and irinotecan) [6,7], cell cycle progression [8], bioenergetics [9,10,11], and stemness [12].