The addition of 200 mg/kg curcumin to the diet may alleviate the jejunum oxidative stress of the IUGR growing pigs and improve the jejunum antioxidant function through the Nrf2/Keap1 pathway, thereby further improving the jejunum immune function of IUGR pigs, and improving jejunal tight junction, but the relevant mechanisms are need further research. The gene discussed is KEAP1; the disease is fetal growth restriction.