The mRNA of adiponectin, which is one of the key compounds in the treatment of diabetes, is expressed by the binding of retinoid X receptor (RXR) and activated PPARγ to peroxisome proliferator response element (PPRE) and Liver Receptor Homolog-1 (LRH-1) binding to LRH-RE on DNA [47]. Here, PPARG is linked to diabetes mellitus.