Similarly, our analysis of the GSE26549 database of gene profiles of ‘patients with oral preneoplastic lesions (OPLs) having high risk of developing oral cancer’ [19], revealed that increases in PI3K (p = 2.66 × 10−6) and STAT3 (p = 1.76 × 10−7) gene expressions were associated with an increased risk of oral cancer (Figure 2C, upper panel), with high PI3K/STAT3 dual-gene expression associated with worse disease-free survival (DFS) (Figure 2C, lower panel). Here, PIK3CA is linked to lip and oral cavity carcinoma.