Consistent with earlier findings, this suppression of the tumor burden and stemness in the OV-alone and CDDP+OV groups was associated with decreased expressions of mTOR, PI3K, STAT3, β-catenin, and TGF-β1 proteins in CSC_EVs generated from tumor samples harvested from OV-alone or CDDP+OV-treated mice, compared to the CDDP-alone- or vehicle-treated groups (Figure 5E). Here, PIK3CA is linked to neoplasm.