In a presentation at the 2019 American Society of Clinical Oncology (ASCO) meeting, AMG 510 was reported to produce partial responses in 50% of patients with KRAS G12C mutant non-small cell lung cancer, while also contributing to stable disease in approximately 77% of enrolled patients with KRAS G12C mutant colorectal or appendix cancers (Figure 3D) [57]. Here, KRAS is linked to non-small cell lung carcinoma.